4-(Aminosulphonyl)benzeneboronic acid
4-(Aminosulphonyl)benzeneboronic acid
CAS: 613660-87-0
Molecular Formula: C6H8BNO4S
4-(Aminosulphonyl)benzeneboronic acid - Names and Identifiers
| Name | 4-(Aminosulphonyl)benzeneboronic acid |
| Synonyms | 4-BORONOBENZENESULFONAMIDE 4-SULFAMOYLPHENYLBORONIC ACID (4-sulfamoylphenyl)boronic acid 4-AMINOSULFONYLPHENYLBORONIC ACID (4-Aminosulfonyl)phenylboronic acid 4-(Aminosulfonyl)phenylboronic acid 4-(Aminosulfonyl)benzeneboronic acid (4-AMINOSULPHONYL)BENZENEBORONIC ACID 4-(Aminosulphonyl)benzeneboronic acid |
| CAS | 613660-87-0 |
| InChI | InChI=1/C6H8BNO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4,9-10H,(H2,8,11,12) |
4-(Aminosulphonyl)benzeneboronic acid - Physico-chemical Properties
| Molecular Formula | C6H8BNO4S |
| Molar Mass | 201.01 |
| Density | 1.53±0.1 g/cm3(Predicted) |
| Melting Point | 250-256 |
| Boling Point | 461.9±55.0 °C(Predicted) |
| Flash Point | 233.176°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 7.85±0.16(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.618 |
4-(Aminosulphonyl)benzeneboronic acid - Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29163990 |
| Hazard Note | Irritant |
4-(Aminosulphonyl)benzeneboronic acid - Introduction
4-(Aminosulphonyl)benzeneboronic acid is an organic compound with the chemical formula C6H8BNO4S. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
4-(Aminosulphonyl)benzeneboronic acid is a solid crystalline compound, soluble in water and organic solvents such as alcohols and ethers. Its melting point is between 200-204°C. This compound has a certain stability, but may decompose under the action of strong oxidants.
Use:
4-(Aminosulphonyl)benzeneboronic acid has a wide range of applications in the field of chemistry and medicine. It is often used as a reagent in organic synthesis, especially in the synthesis of phenylboronic acid ligands. This compound can participate in the palladium-catalyzed Suzuki coupling reaction and thus be used to construct carbon-carbon bonds. In addition, it can also be used as an intermediate for pharmaceutical research and preparation.
Preparation Method:
The preparation of 4-(Aminosulphonyl)benzeneboronic acid is usually obtained by reacting phenylboronic acid with 4-aminosulfonyl chloride. The reaction raw materials react under alkaline conditions to generate 4-(Aminosulphonyl)benzeneboronic acid, which is finally purified by crystallization to obtain the target product.
Safety Information:
4-(Aminosulphonyl)benzeneboronic acid is generally a relatively safe compound, but it is still necessary to pay attention to safe operation. It may cause irritation to the skin, eyes and respiratory tract, so you should wear appropriate protective measures to avoid contact with skin and eyes. At the same time, operate in a well-ventilated environment to avoid inhaling aerosols or dust. If inadvertent contact or accidental exposure occurs, flush the affected area immediately with water and seek medical help.
Nature:
4-(Aminosulphonyl)benzeneboronic acid is a solid crystalline compound, soluble in water and organic solvents such as alcohols and ethers. Its melting point is between 200-204°C. This compound has a certain stability, but may decompose under the action of strong oxidants.
Use:
4-(Aminosulphonyl)benzeneboronic acid has a wide range of applications in the field of chemistry and medicine. It is often used as a reagent in organic synthesis, especially in the synthesis of phenylboronic acid ligands. This compound can participate in the palladium-catalyzed Suzuki coupling reaction and thus be used to construct carbon-carbon bonds. In addition, it can also be used as an intermediate for pharmaceutical research and preparation.
Preparation Method:
The preparation of 4-(Aminosulphonyl)benzeneboronic acid is usually obtained by reacting phenylboronic acid with 4-aminosulfonyl chloride. The reaction raw materials react under alkaline conditions to generate 4-(Aminosulphonyl)benzeneboronic acid, which is finally purified by crystallization to obtain the target product.
Safety Information:
4-(Aminosulphonyl)benzeneboronic acid is generally a relatively safe compound, but it is still necessary to pay attention to safe operation. It may cause irritation to the skin, eyes and respiratory tract, so you should wear appropriate protective measures to avoid contact with skin and eyes. At the same time, operate in a well-ventilated environment to avoid inhaling aerosols or dust. If inadvertent contact or accidental exposure occurs, flush the affected area immediately with water and seek medical help.
Last Update：2024-04-09 21:11:58
